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The Dallas Cowboys and New York Giants will surprise again in Week 6

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NFL Anti-Spread Picks return with a look at the most valuable Week 6 games of the 2022 NFL regular season.

The fifth week in the league offered some big surprises and a few outright awakenings. The most notable of the results was the stunning victory of the New York Giants against the Green Bay Packers in London. Not to be outdone, the Jets also pulled off a monumental victory of their own as they outscored the rival Miami Dolphins 40-17. The San Francisco 49ers, New England Patriots and Buffalo Bills also had dominant wins last weekend.

In Week 6, the league will have a few back-to-back games this Sunday. The best of which are a pair of divisional matchups at 4:25 PM ET. First, Josh Allen and the Bills face Patrick Mahomes and the Chiefs in Kansas City. At the same time, the red-hot Cowboys travel to Philadelphia to take on the top-ranked Eagles.

Also read: Everything you need to know about NFL Sunday Ticket

In this latest edition of the column, we’ll focus on the five games (listed below) that they offer NFL anti-spread picks worth your bet.

The game time (ET) TV
Buccaneers (-8) @ Steelers 13:00 CBS
Ravens @ Giants (+6) 13:00 FOX
Panthers @ Rams (-10) 16:25 FOX
Cowboys (+6.5) @ Eagles 20:20 NBC
Broncos @ Chargers (-5) 20:15 ESPN

Tom Brady and the Tampa Bay Buccaneers will make it easy for the Steelers

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Credit: Kim Clement-USA TODAY Sports

Tom Brady and the Tampa Buccaneers are pretty heavy favorites against rookie QB Kenny Pickett and the Steelers on Sunday. A -8 betting favorite to be exact. While that’s a big number, the combination of Brady — a player who has put up big numbers despite not yet playing at his typical level — and Pittsburgh’s terrible defense looks combustible.

After a couple of upsets last week in similar pairings, look for the QB legend and the Bucs to hurt the Steelers and win by two or more touchdowns in these NFLs.

2022 NFL Power Rankings: Week 6 sees the rise of the Dallas Cowboys and Baltimore Ravens

New York Giants stun Ravens at home

The New York Giants, especially their defense, has been one of the biggest surprises this season. However, that D will be tested on Sunday by the multi-dimensional threat that is Lamar Jackson. Fortunately for Big Blue, the Ravens defense has been one of the worst in the league and will certainly give the Giants plenty of opportunities to put points on the board.

Look for the Giants to be competitive against the Ravens and keep things closer than the +6 odds they have. While they may not be a surefire pick to win outright, in these NFL picks against the spread they are a great option.

The Los Angeles Rams are taking out a losing streak on the Panthers

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Credit: Robert Hanashiro-USA TODAY Sports

The Los Angeles Rams will not be in a good mood on Sunday afternoon. They lost back-to-back games, and pretty handily, to the San Francisco 49ers and Dallas Cowboys. A struggling Carolina Panthers team expected to be without starting quarterback Baker Mayfield will come to town and will have a new interim head coach after Matt Rhule was fired this week.

The Panthers already had one of the worst offenses in the league with a healthy Mayfield. Now, with PJ Walker starting, the Rams being a -10 favorite seems like a conservative expectation. That’s why they’re a good option this week in the NFL picks against the spread because a three-TD LA win wouldn’t be surprising.

The Dallas Cowboys defense keeps it close against the Eagles

The Cowboys vs. Eagles game on Sunday afternoon is one of the biggest of the weekend. Starting QB Dak Prescott isn’t expected to suit up yet, but his weeks-long absence hasn’t slowed their climb to the top of the division. The Eagles have one of the best defenses in the NFL and will challenge backup signal caller Cooper Rush in a way he hasn’t before.

In the 2022 NFL rankings, Josh Jacobs and the Raiders offense caught fire

However, the same could be said for Jalen Hurts against an elite Cowboys defense. This could definitely be a low-scoring defensive war of attrition, and games like that are often contested affairs. That’s why the Cowboys topping the +6.5 spread is one of our top NFL picks of the week.

The Los Angeles Chargers will be electrifying against the Denver Broncos

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Credit: Troy Taormina-USA TODAY Sports

While Russell Wilson and the Denver Broncos’ offense was a big disappointment in 2022, the defense was strong. They are what will keep them in the game against Justin Herbert and the Los Angeles Chargers offense. However, expect the Broncos O to underperform again and allow the Chargers to control the ball and eventually wear down Denver’s defense. Which means they will beat the -6 odds they have this Sunday.

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